BMJ Case Reports 2009; doi:10.1136/bcr.07.2009.2084
  • Unexpected outcome (positive or negative) including adverse drug reactions

Reversible hyponatraemia with venlafaxine in a young patient

  1. Qaiser Javed1,
  2. Faouzi Alam2,
  3. Sowmya Krishna2
  1. 1
    Wirral University Teaching Hospital, Psychiatry, Clatterbridge Hospital, Bebington, Wirral CH63 4JY, UK
  2. 2
    Clatterbridge Hospital, Psychiatry, Bebington, Wirral CH63 4JY, UK
  1. Qaiser Javed, drqaser{at}
  • Published 22 November 2009


A 28-year-old woman with a depressive episode developed hyponatraemia (126 mmol/l), in the absence of hypovolaemia, oedema, or diuretic use, 2 weeks after starting treatment with the antidepressant venlafaxine. Full blood count, potassium, urea, creatinine, thyroid function test, liver function test, amylase, serum cortisol, and glucose were all normal. A repeat blood test 3 days later revealed a further reduction in the sodium concentration to 123 mmol/l. The patient did not have any signs or symptoms of physical disorder secondary to hyponatraemia on this occasion. Her serum sodium reached normal values 2 weeks after stopping treatment with venlafaxine. Hyponatraemia secondary to venlafaxine has been reported in the older population but not in young people. We therefore believe this is an important finding.


  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication

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