Enteropathy associated T cell lymphoma: common in coeliac disease
- Gabrielle Christina Colleran1,
- Kevin Christopher Cronin2,
- Mary Casey3,
- Fadel Bennani4,
- Iqdam Tobbia4,
- Kevin Barry5
- 1Galway University Hospital, Surgery, Newcastle, Galway, Ireland
- 2Galway University Hospital, Cardio-Thoracic Surgery, Newcastle, Galway, Ireland
- 3Mayo General Hospital, Radiology, Castlebar, Mayo, Ireland
- 4Mayo General Hospital, Pathology, Castlebar, Mayo, Ireland
- 5Mayo General Hospital, Surgery, Castlebar, Mayo, Ireland
- Published 23 February 2009
A 56-year-old male admitted with haematemesis and epigastric pain and severe weight loss on a background of coeliac disease. Computed tomography (CT) abdomen revealed a thickening of the mucosal folds of a short segment of jejunum. He deteriorated and had an exploratory laparotomy and bowel resection with side-side jejojejunal stapled anastomosis and extended right hemicolectomy and ileocolic anastomosis. Histology demonstrated multifocal high-grade malignant T cell lymphoma. Coeliac disease is a very common lifelong disorder. It is associated with osteoporosis, infertility, autoimmune disorders and increased risk of malignancy including an increased risk of non-Hodgkin’s lymphoma (NHL) especially of the T cell type. Enteropathy-type T cell lymphoma is associated with a very poor prognosis. There is significant evidence that adherence to a gluten-free diet decreases the risk of developing enteropathy-type T cell lymphoma and helps to prevent development of autoimmune diseases, diabetes mellitus and osteoporosis in patients with coeliac disease.
Competing interests: none.