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Rhabdomyolysis caused by an interaction of simvastatin and fusidic acid

Summary

A case of severe rhabdomyolysis caused by an interaction between fusidic acid and simvastatin is described. Fusidic acid significantly reduces the excretion of simvastatin resulting in increased plasma levels thereby increasing the side effect profile. Simvastatin treatment should be temporarily withheld during treatment with fusidic acid.

https://doi.org/10.1136/bcr.03.2009.1722

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