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BMJ Case Reports 2009; doi:10.1136/bcr.03.2009.1722
  • Learning from errors

Rhabdomyolysis caused by an interaction of simvastatin and fusidic acid

  1. Roselle Herring,
  2. Gordon Caldwell,
  3. Stuart Wade
  1. Worthing and Southlands NHS Trust, Endocrine and Diabetes, Worthing Hospital, Lyndhurst Road, West Sussex, BN11 2DH, UK
  1. Roselle Herring, roselle.herring1{at}btinternet.com
  • Published 20 September 2009

Summary

A case of severe rhabdomyolysis caused by an interaction between fusidic acid and simvastatin is described. Fusidic acid significantly reduces the excretion of simvastatin resulting in increased plasma levels thereby increasing the side effect profile. Simvastatin treatment should be temporarily withheld during treatment with fusidic acid.

Footnotes

  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.

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