BMJ Case Reports 2009; doi:10.1136/bcr.01.2009.1529
  • Other full case

A case of recurrent gastrinoma in the liver with a review of “primary” hepatic gastrinomas

  1. Cornelis Lamers
  1. Leiden University Medical Center, Gastroenterology, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
  1. Patricia Kuiper, p.kuiper{at}
  • Published 11 June 2009


The present report concerns a patient with a malignant gastrin-producing neuroendocrine tumour (ie, Zollinger–Ellison syndrome) with recurrent hepatic gastrinomas, in whom no gastrinoma in the duodenum, pancreas or other extrahepatic sites could be identified despite the use of multiple, repeatedly performed imaging and exploration techniques over the past 20 years. A short review on primary liver gastrinomas published since 1981 is also given. Interestingly, our patient is the only case with documented recurrent gastrinoma in the liver. None of the cases in the literature had liver gastrinomas as part of the multiple endocrine neoplasia type I syndrome. The interpretation of hepatic gastrinomas as primary lesions is questionable unless comprehensive investigation and well documented long-term follow-up is performed.


  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.

No Related Web Pages

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article