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Description
A 69-year-old Caucasian women presented to the clinic with haemoptysis. Review of the systems was otherwise negative. Her medical history was significant for uterine carcinosarcoma, which was diagnosed 3 years ago and treated with total hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node dissection with chemotherapy and radiation therapy.
Physical examination was non-contributory. Chest X-ray (CXR) revealed right upper lobe mass-like density concerning for a malignancy (figure 1).
Subsequent CT of the chest was performed, which showed bilateral lung masses (figure 2).
CT-guided biopsy of the lung mass was performed and pathology examination showed poorly differentiated carcinoma, consistent with metastatic uterine carcinosarcoma, with marked nuclear polymorphism, abundant foamy cytoplasm and areas of surrounding necrosis (figure 3). Compared with the patient's original uterine carcinosarcoma the morphological findings were similar.
The patient was started on ifosfamide and cisplatin, with radiological resolution after five cycles of chemotherapy. One year later, the patient denied any complaint and chest radiograph did not show any evidence of metastatic tumour.
Uterine carcinosarcomas include a heterogeneous group of rare tumours that usually have an aggressive behaviour and pertain a poor prognosis. Numbers of recent studies have examined the influence of radiation, chemotherapy and combinations of chemotherapy and radiation for the incidence of uterine carcinosarcoma.1 The management consists of surgical resection and chemotherapy with isofosfamide and/or cisplatin. However, some clinical studies failed to show any incremental benefit combining these medications.2 On the other hand, a separate phase III trial showed that compared with ifosfamide alone, ifosfamide plus cisplatin resulted in a higher response rate and a significant improvement in progression-free survival.3
Learning points
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Uterine carcinosarcomas (previously called malignant mixed Müllerian tumours) are dedifferentiated (metaplastic) carcinomas comprised of carcinomatous and sarcomatous elements arising from a single malignant clone.
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While both components must be present in the uterine specimen to make this diagnosis, metastatic sites are generally composed of the carcinomatous (epithelial) portion.
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The management of the primary tumour consists of surgical resection, radiotherapy and chemotherapy with isofosfamide and/or cisplatin. Chemotherapy is the main treatment for metastatic disease.
Footnotes
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Competing interests None.
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Patient consent Obtained.
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Provenance and peer review Not commissioned; externally peer reviewed.