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  • Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia

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CASE REPORT
Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia
  1. Burcu Belen1,
  2. Burcu Ozturk Hismi2,
  3. Ulker Kocak3
  1. 1Department of Pediatric Hematology and Oncology, Gaziantep Childrens’ Hospital, Gaziantep, Turkey
  2. 2Department of Pediatrics and Inborn Errors of Metabolism, Gaziantep Childrens’ Hospital, Gaziantep, Turkey
  3. 3Department of Pediatric Hematology, Gazi University School of Medicine, Ankara, Turkey
  1. Correspondence to Dr Burcu Belen, draida{at}yahoo.com

Summary

Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.

https://doi.org/10.1136/bcr-2014-203742

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