Images in...

Asymptomatic spontaneous resolution of a giant fusiform M2–M3 dissecting aneurysm in a teenager

M Cellerini, S Mangiafico

Interventional Neuroradiology, Careggi Hospital, Florence, Italy

Correspondence to:
martino.cellerini{at}fastwebnet.it

A 16-year-old female was admitted to hospital due to intermittent right-sided headaches. On admission, physical and neurological examinations yielded no unusual findings. She underwent a MRI and angiography (MRI-MRA) (fig 1A–C) that showed a fusiform dilatation of the right middle cerebral artery (MCA) division branches. A subsequent plain CT scan of the head and a lumbar puncture revealed no subarachnoid bleeding. Two weeks later, catheter angiography (DSA) showed a stenosis-dilatation-stenosis pattern (pearl-and-string sign) of the lower division branch of the right MCA, consistent with dissection (fig 1D). To exclude a mycotic or infective cause, the patient was analysed with a complete cardiological check-up that yielded no positive findings. The girl was discharged as she was completely asymptomatic. A follow-up MRI (fig 1E) and DSA (fig 1F) 18 months later showed complete resolution of the initial findings. Giant (>2.5 cm in length) fusiform aneurysms are spindle-like lesions that involve the main part of the arterial circumference. They account for 5–17% of giant aneurysms, which, in turn, represent 3–13% of all intracranial aneurysms.¹ Their location at the division (M2–M3) branches of the MCA is fairly uncommon, although they may occur—particularly in young people. These aneurysms may be associated with trauma, infection, inflammation, atherosclerosis or spontaneous dissection. Giant fusiform aneurysms are usually a cause of cerebral ischaemia or subarachnoid haemorrhage. Their natural history is not known, but partial thrombosis is common; however, complete spontaneous resolution is very rare and often associated with ischaemic symptoms.² Most unusually in our patient, complete resolution of the lesion occurred without clinical events. In the past, two cases of aneurysms with asymptomatic total resorption have been reported.^{2 3} Crescent-like high signal intensity around a signal void is the hallmark of dissection on MRI. The high signal corresponds to an intramural haematoma. However, the rate of intramural haematoma shown on MRI ranges from 32% to 100%, according to the timing of MRI. DSA still remains the "gold standard" imaging method for diagnosis, MRI-MRA being an alternative when repeated examinations are required.⁴ The double lumen sign (intimal flap with contrast stagnation), stenosis with dilatation (pearl-and-string sign), dilatation without stenosis (string sign) and stenosis without dilatation or occlusion (tapered occlusion) represent the hallmarks of arterial dissection on DSA. Stenosis is usually not focal but extensive, and serial changes are seen on follow-up examinations. Management of intracranial giant fusiform aneurysms is controversial; surgical and endovascular approaches (eg, proximal occlusion or trapping with or without bypass) are both technically demanding and high-risk procedures.⁵ The spontaneous regression of the lesion without clinical consequences in our patient suggest that conservative treatment may represent a valid alternative in patients with asymptomatic giant fusiform dissecting cerebral aneurysms.

View this figure (122K): in this window | in a new window | PowerPoint for Teaching   Figure 1 Axial T2-w and coronal T1-w MRI images. (A, B) A 2-cm round mass in the right Silvian fissure, characterised by a flow-void (patent lumen) adjacent to a crescent-like, high signal intensity mural haematoma. Both compartments show what is depicted as a long fusiform dilatation of a middle cerebral artery (MCA) division on ToF-MRA (C). Two weeks later, catheter angiography (DSA) (D) showed a stenosis-dilatation-stenosis pattern (pearl-and-string sign) of the lower MCA division branch, consistent with arterial dissection. Note the opening of the MCA bifurcation branches due to a mass effect from the thrombosed compartment of the fusiform aneurysm. Discrepancies between MRI and angiography (MRI-MRA) (A–C) and DSA (D) findings is consistent with a progressive thrombosis of the aneurysm. Follow-up axial T2-w MRI (E) and DSA (F) 18 months later showed complete resolution of findings, with resorption of the thrombosed compartment (no mass effect) and remodelling of the vessel lumen (no vessel lumen abnormalities).

 

This article has been adapted from Cellerini M, Mangiafico S. Asymptomatic spontaneous resolution of a giant fusiform M2–M3 dissecting aneurysm in a teenager Journal of Neurology, Neurosurgery and Psychiatry 2008;79:863

Competing interests: None declared.

Patient consent: Informed patient consent was obtained for publication of the case details described in this report.

1. al-Yamany, M, & Ross, IB. Giant fusiform aneurysm of the middle cerebral artery: successful Hunterian ligation without distal by-pass. Br J Neurosurg 1998;12:572–5.[CrossRef][Medline]
2. Krapf, H, Schoning, M, Petersen, D, et al.Complete asymptomatic thrombosis and resorption of a congenital giant intracranial aneurysm. Case report. J Neurosurg 2002;97:184–9.[Medline]
3. Iplikcioglu, AC, Dinc, C, Bek, S, et al.Spontaneous thrombosis and resorption of a giant fusiform A2 aneurysm. Case illustration. J Neurosurg 2006;105:788.[CrossRef][Medline]
4. Yoshimoto, Y, & Wakai, S. Unruptured intracranial vertebral artery dissection: clinical course and serial radiographic imaging. Stroke 1997;28:370–4.[Abstract/Free Full Text]
5. Fuentes, S, Levrier, O, Metellus, P, et al.Giant fusiform intracranial A2 aneurysm: endovascular and surgical treatment. Case illustration. J Neurosurg 2004;101:704.[Medline]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?