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CASE REPORT
Amyloidosis: an unusual cause of upper gastrointestinal bleeding
  1. Keith Siau1,2,
  2. Amera Elzubeir2,
  3. Sheldon C Cooper2,
  4. Tariq Iqbal3
  1. 1Department of Gastroenterology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK
  2. 2University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
  3. 3Department of Gastroenterology, Queen Elizabeth Hospital, Birmingham, UK
  1. Correspondence to Dr Keith Siau, keith{at}siau.org

Summary

We report a rare case of upper gastrointestinal bleeding in a 55-year-old man with monoclonal gammopathy of unknown significance presenting with abdominal pain, weight loss and melaena. Gastroscopy was unremarkable, but melaena persisted, with the development of symptomatic anaemia. While colonoscopy excluded a lower gastrointestinal aetiology, CT revealed jejunitis, confirmed at capsule endoscopy. Histopathological examination of specimens obtained at single balloon enteroscopy revealed an unusual aetiology: small bowel AL-amyloidosis. We review his clinical presentation, radiological, endoscopic and histological findings and review the literature of this unusual condition.

https://doi.org/10.1136/bcr-2016-217653

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    Footnotes

    • Contributors KS wrote the case presentation and discussion, AE helped with the case presentation, SCC and TI contributed to the discussion and provided guidance for the case report. All authors read and approved the manuscript prior to submission.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.