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CASE REPORT
Metronidazole-induced encephalopathy after prolonged metronidazole course for treatment of C. difficile colitis
  1. Mark S Godfrey1,
  2. Arkadiy Finn2,
  3. Hadeel Zainah3,
  4. Kwame Dapaah-Afriyie4
  1. 1Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
  2. 2Department of Medicine, Warren Alpert School of Medicine, Brown University, The Miriam Hospital, Providence, Rhode Island, USA
  3. 3The Miriam Hospital, Providence, Rhode Island, USA
  4. 4Department of Medicine, The Miriam Hospital, Providence, Rhode Island, USA
  1. Correspondence to Dr Arkadiy Finn, afinn1{at}lifespan.org

Summary

A 65-year-old woman with a diagnosis of Clostridium difficile colitis undergoing prolonged treatment with metronidazole was admitted to hospital for altered mentation, slurred speech and weakness. She was diagnosed with metronidazole-induced encephalopathy, confirmed with brain MRI and improved when the offending agent was removed. This case report highlights encephalopathy as a complication of prolonged metronidazole treatment, which has become more common in clinical practice for the treatment of C. difficile infection.

https://doi.org/10.1136/bcr-2014-206162

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