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Published 20 September 2009
Cite this as: BMJ Case Reports 2009 [doi:10.1136/bcr.03.2009.1722]
Copyright © 2009 by the BMJ Publishing Group Ltd.

Learning from errors

Rhabdomyolysis caused by an interaction of simvastatin and fusidic acid

Roselle Herring, Gordon Caldwell, Stuart Wade

Worthing and Southlands NHS Trust, Endocrine and Diabetes, Worthing Hospital, Lyndhurst Road, West Sussex, BN11 2DH, UK

Correspondence to:
Roselle Herring, roselle.herring1{at}btinternet.com

SUMMARY

A case of severe rhabdomyolysis caused by an interaction between fusidic acid and simvastatin is described. Fusidic acid significantly reduces the excretion of simvastatin resulting in increased plasma levels thereby increasing the side effect profile. Simvastatin treatment should be temporarily withheld during treatment with fusidic acid.


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