Unexpected outcome (positive or negative) including adverse drug reactions
Prolonged use of atosiban and grade IV intraventricular haemorrhage in an infant born at 29 weeks and 4 days
UZA, Obstetrics, Wilrijkstraat 10, Edegem, 2650, Belgium
Correspondence to:
Yves Jacquemyn, yves.jacquemyn{at}uza.be
A woman in her second pregnancy (G2P1), with a prior history of preterm birth at 21 weeks, had been using vaginal progesterone suppositories as prophylaxis and presented with cervical shortening and funnelling. At 24 weeks, betamethasone and nifedipine was started because of contractions. At 26 weeks, a new period of preterm contractions emerged and atosiban was added. Attempts were made to stop administration of atosiban, but every time the contractions returned. At 27 weeks the decision was made to continue atosiban and nifedipine until a gestational age of 30 weeks. At 29 weeks and 4 days she went into labour and delivered vaginally after a very short second stage. The baby weighed 1340 g with a 5-minute Apgar score of 8. The infant was admitted to the neonatal intensive care ward. On day 3, a diagnosis was made of grade IV intraventricular haemorrhage.
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