Rare disease
Diffuse intestinal angiomatosis as a possible paraneoplastic manifestation of small cell lung cancer: a case of small bowel angiomatosis
1 University Hospital Birmingham, Department of Gastroenterology, Queen Elizabeth Hospital, Edgbaston, Birmingham B156HT, UK
2 War Lane, Harborne, Birmingham B179RR, UK
3 University Hospital Birmingham, Colorectal surgeon, Queen Elizabeth Hospital, Edgbaston, Birmingham B156HT, UK
4 University Hospital Birmingham, Radiology, Queen Elizabeth Hospital, Edgbaston, Birmingham B156HT, UK
5 University Hospital Birmingham, Histopathology, Queen Elizabeth Hospital, Edgbaston, Birmingham B156HT, UK
Correspondence to:
Adam Low, aelow{at}doctors.org.uk
Vascular malformations are rare, incompletely understood and heterogeneous in presentation and clinical course. They are known to be associated with a number of benign syndromes, commonly presenting in childhood. Angiomatosis is a form of vascular malformation, hardly documented in the English literature, and has only rarely been described in the small bowel. We present a case of a middle-aged female who developed small bowel obstruction secondary to diffuse small bowel angiomatosis and subsequently developed aggressive multifocal small cell lung cancer 2 months later. Her condition rapidly deteriorated with multiple metastases and she passed away 4 months later secondary to brain metastases and diffuse disease. Small cell lung cancer is well known for its association with paraneoplastic syndromes and has been reported to cause a rise in vascular endothelial growth factor. We postulate that in this case angiomatosis presented as a paraneoplastic syndrome associated with small cell lung cancer.
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