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Published 17 March 2009
Cite this as: BMJ Case Reports 2009 [doi:10.1136/bcr.06.2008.0235]
Copyright © 2009 by the BMJ Publishing Group Ltd.

Rare disease

Neuro-regression in vitamin B12 deficiency

Sanwar Agrawal, Shweta Nathani

Ekta Institute of Child Health, Pediatrics, Near Ram Mandir, Shantinagar, Raipur 492001, India

Correspondence to:
Sanwar Agrawal, drsanwar50{at}gmail.com

SUMMARY

Neuroregression in infants has varied aetiology and vitamin B12 deficiency is one of the uncommon causes. Infantile vitamin B12 deficiency is encountered in malnourished infants or in offspring of strict vegan mothers. We present two cases, both infants of 10 and 8 months of age, whose mothers had vitamin B12 deficiency. On admission, the patients were apathic, hypotonic and lethargic. Serum vitamin B12 levels were below normal limits. On cranial MRI, T2-weighted images revealed frontoparietal cortical atrophy. Both the infants responded to vitamin B12 treatment.


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