Unexpected outcome (positive or negative) including adverse drug reactions
Metformin-induced cholangiohepatitis
1 Case Western Reserve University @ MetroHealth Medical Center, Hospital Medicine, 2500 MetroHealth Dr, Cleveland, Ohio, 44138, USA
2 Gastroenterology of Canton Inc, 4124 Munson Rd NW, Canton, Ohio, 44718, USA
3 Mercy Medical Center, 1320 Mercy Dr NW, Canton, Ohio, 44708, USA
4 NEOUCOM, Gastroenterology, Gastroenterology of Canton Inc, 4124 Munson St NW, Canton, Ohio, 44718, USA
Correspondence to:
Raja Shekhar Reddy Sappati Biyyani, rsappati{at}hotmail.com
Drug-induced cholangiohepatitis accounts for 20–50% of non-viral chronic hepatitis cases. Metformin is the most commonly prescribed oral anti-diabetic drug from the biguanide class used in treatment of overweight and obese type 2 diabetes mellitus patients. Metformin-induced cholangiohepatitis with marked elevations in serum liver transaminases and intrahepatic cholestasis has been infrequently reported. Here, we report a case of acute cholangiohepatitis after initiation of metformin treatment.
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