Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?
1 Liverpool John Moores University, Research Institute for Sport and Exercise Science, Henry Cotton Campus, Truman Street, Liverpool, L3 2ET, UK
2 CRY Centre for Sports Cardiology, Olympic Medical Institute, Northwick Park Hospital, Harrow, HA1 3UJ, UK
3 The Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
4 Liverpool John Moores UNiversity, Research Institute for Sport and Exercise Science, Henry Cotton Campus, Liverpool, L3 2ET, UK
5 Brunel University, Uxbridge, London, UB1, UK
6 Kings College Hospital, Denmark Hill, London, SE5 9RS, UK
Correspondence to:
gregwhyte27{at}yahoo.co.uk
We report the case of an experienced, highly trained marathon runner who died suddenly while running. On post-mortem examination, left ventricle hypertrophy and idiopathic interstitial myocardial fibrosis was found. We believe that life-long, repetitive bouts of arduous physical activity resulted in fibrous replacement of the myocardium, causing a pathological substrate for the propagation of fatal arrhythmias.
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