Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes
1 Department of Neurology, Hôpital Gui-de-Chauliac, Montpellier, France
2 Immunology Laboratory, Hôpital Saint-Eloi, Montpellier, France
3 INSERM U888, Hôpital de la Colombière, Montpellier, France
Correspondence to:
b-carlander{at}chu-montpellier.fr
Devic’s neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.
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