Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Motor worsening and tardive dyskinesia with aripiprazole in Lewy body dementia
1 New York University School of Medicine, Neurology, New York, NY10016, USA
2 Bellevue Hospital Center, Dept of Neurology, New York, NY10016, USA
3 VA NY Harbor Healthcare System, Department of Neurology, New York, NY10010, USA
4 New York University, Psychiatry, New York, NY10016, USA
Correspondence to:
laura.boylan{at}nyumc.org
Aripiprazole (APZ) is a novel antipsychotic agent which does not block dopamine (DA) receptors but is rather a partial DA agonist. Thus, it has been proposed that APZ may not induce tardive dyskinesia (TD), a disfiguring and sometimes disabling and irreversible side effect of neuroleptics. Our patient had Lewy body dementia (LBD) and developed severe worsening of parkinsonism over 1 month of APZ treatment. Within days of discontinuation of APZ dramatic orobuccal dyskinesias emerged. Treatment emergent worsening of parkinsonism improved but orobuccal dyskinesias persisted unchanged until his death 8 months later. Others have reported severe extrapyramidal reactions including neuroleptic malignant syndrome and TD with APZ. APZ has been suggested as a treatment for TD but treatment benefit may reflect "masked" dyskinesia. We conclude that, despite an attractive in vitro profile and promising animal data, APZ can induce serious extrapyramidal side effects, including TD.
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Drugs: CNS (not psychiatric)
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