Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus
1 Department of Internal Medicine, Jichi Medical University, Tochigi, 329-0498, Japan
2 Jichi Medical Unversity, Internal medicine, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0498, Japan
3 University of Pennsylvania, Neurology, 3W Gates, Philadelphia, Pennsylvania, 19104, United States
Correspondence to:
hshimaza{at}jichi.ac.jp
The authors report a patient with limbic encephalitis associated with an ovarian teratoma. An antibody against the membranes of neurones of the hippocampus was identified in both serum and CSF. Immunosuppressive treatments such as plasmapheresis and high-dose intravenous immunoglobulin administration resulted in a rapid clinical recovery.
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