Unexpected outcome (positive or negative) including adverse drug reactions
Improvement in sleep apnoea associated with switch from simvastatin to pravastatin
1 University of California, San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, California, 92093-0995, USA
2 University of California, San Diego, Department of Medicine, Department of Family and Preventive Medicine, 9500 Gilman Drive, La Jolla, California, 92093-0995, USA
Correspondence to:
Beatrice Alexandra Golomb, bgolomb{at}ucsd.edu
Sleep problems have been reported as an adverse effect of statins. In a randomised trial, simvastatin at 20 mg produced significantly worse sleep quality than either placebo or pravastatin 40 mg. A possible relation to sleep apnoea was hypothesised. Here, the case of a 67-year-old man who experienced sleep apnoea on simvastatin 20 mg is presented. Objective nightly testing showed a prompt, marked, sustained and statistically significant improvement in the obstructive apnoea index when the patient switched to pravastatin 20 mg.
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Drugs: cardiovascular system
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