Reminder of important clinical lesson
Meningomyelocele: the tip of the iceberg
1 Nair Hospital, Department of Histopathology, Nair Road, Mumbai, Maharashtra, 400008, India
2 Royal Sussex County Hospital, Histopathology, Royal Sussex County Hospital, Eastern Road, Brighton, BNQ 5BE, UK
Correspondence to:
Shikha Singhal, shikha79{at}doctors.org.uk
Meningomyelocele is one of the commonest neural tube closure defects. A 2-month-old girl presented with meningomyelocele in the lumbosacral region that had been present since birth. She had experienced paraparesis for 1 month. Terminally, she had excessive crying, and died within 1 week of presentation. An autopsy revealed focally infected meningomyelocele with features of Arnold–Chiari II malformation. Associated malformations included polymicrogyria, neuronal heterotopias and neuronal cytomegaly in the brainstem. Cortical malformations may be detected radiologically, thus prompting surgical intervention and reduced mortality. By contrast, the presence of cytomegaly may hinder postsurgical improvement, affecting intellectual outcome in survivors in particular. New genetic revelations also offer a scope for genetic counselling in these conditions.
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