Unusual presentation of more common disease/injury
Endometrioid adenocarcinoma presenting in a patient 18 years after hysterectomy: a potential hazard of unopposed oestrogen therapy
1 Stoke Mandeville Hospital, Obstetrics and Gynaecology, Flat C, 17-19 Guildford Street, Luton LU1 2NQ, UK
2 Royal Blackburn Hospital, Obstetrics & Gynaecology, Haslingden Road, Blackburn BB2 3HH, UK
3 Royal Blackburn Hospital, Pathology, Haslingden Road, Blackburn BB2 3HH, UK
4 Leicester Royal Infirmary, Dermatology, Infirmary Square, Leicester LE1 5WW, UK
Correspondence to:
Alvaro Bedoya Ronga, abedoyaronga{at}yahoo.co.uk
We present a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy. After the primary surgery the patient received 11 years of unopposed oestrogen hormone replacement therapy. She presented with symptoms of urinary retention and pelvic mass. Following resection, histopathology identified the mass as an endometrioid adenocarcinoma. The association between persistent endometriosis and the development of endometrial cancer are discussed here together with the risks of unopposed oestrogen in the development of such lesions.
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