Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Multiple mononeuropathy following cocaine abuse
1 Department of Clinical Neurophysiology, Danish Epilepsy Canter, Visbys Allé 5, 4293 Dianalund
2 Glostrup Hospital, Department of Neurology, Nordre Ringvej, Glostrup, 2600, Denmark
3 Glostrup Hospital, Department of Clinical Neurophysiology, Nordre Ringvej, Glostrup, 2600, Denmark
Correspondence to:
Kjeld Andersen, kva{at}dadlnet.dk
A 31-year-old man with acute-onset of left-sided weakness following the sniffing of cocaine was admitted with rhabdomyolysis. Neurophysiological studies showed axonal degeneration in 4/10 sensory and 3/8 motor nerves, and conduction block outside the typical compression-sites in 3/8 motor nerves. The findings are consistent with a diagnosis of multiple mononeuropathy. Ischaemia due to vasoconstriction is currently believed to be the cause of muscle necrosis following cocaine abuse and we hypothesise that it also explains the neuropathy in this case.
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