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Published 3 April 2009
Cite this as: BMJ Case Reports 2009 [doi:10.1136/bcr.07.2008.0460]
Copyright © 2009 by the BMJ Publishing Group Ltd.

Unusual association of diseases/symptoms

Sleep disruption following paramedian pontine stroke

Matteo Tosato1, Sara Aquila1, Giacomo della Marca2, Raffaele Antonelli Incalzi3, Giovanni Gambassi4

1 Università Cattolica del Sacro Cuore, Centro di Medicina dell’Invecchiamento, Largo Agostino Gemelli 8, Rome 00168, Italy
2 Università Cattolica del Sacro Cuore, Istituto di Neurologia, Largo Agostino Gemelli 8, Rome 00168, Italy
3 Università Campus Biomedico, Divisione di Geriatria, Largo Agostino Gemelli 8, Rome 00168, Italy
4 Università Cattolica del Sacro Cuore, Centro di Medicina dell’Invecchiamento, Largo Agostino Gemelli 8, Rome 00168, Italy

Correspondence to:
Matteo Tosato, mtosato{at}gmail.com

SUMMARY

Pontine structures are critical for the generation of rapid eye movement sleep but there are only a few reports of the effects of focal pontine lesions on sleep patterns in humans. We report the case of an 81-year-old man admitted for the acute onset of disordered speech and motor deficit in the upper right arm who developed hypersomnia within a week. A 24-hour polysomnographic study revealed a very severe disruption of both circadian rhythm and sleep organisation, and a brain MRI documented an ischaemic lesion of the anterior left paramedian portion of the pons. Our observation suggests that even small, paramedian pontine ischaemic lesions can acutely induce a very severe sleep disorder.


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